1. Press Win + R keyboard accelerator to open Run dialog box.
2. Type GPedit.msc and hit Enter or OK to open Local Group Policy Editor.
3. Navigate to Local Computer Policy → Computer Configuration → Administrative Templates → Windows Components → OneDrive.
4. In the right pane, double click on policy named Prevent the usage of OneDrive for file storage.
5. Select the Enabled radio button.
6. Click or tap OK when done.

disable_onedrive64.reg

Windows Registry Editor Version 5.00
 
[HKEY_LOCAL_MACHINE\SOFTWARE\WOW6432Node\Policies\Microsoft\Windows Defender]
"DisableAntiSpyware"=dword:00000001
 
[HKEY_LOCAL_MACHINE\SOFTWARE\Policies\Microsoft\Windows Defender]
"DisableAntiSpyware"=dword:00000001

disable_onedrive32.reg

Windows Registry Editor Version 5.00
 
[HKEY_LOCAL_MACHINE\SOFTWARE\Policies\Microsoft\Windows Defender]
"DisableAntiSpyware"=dword:00000001

killonedrive.cmd

taskkill /f /im OneDrive.exe
taskkill /f /I'm OneDriveSetup.exe

• 32 bit

%SystemRoot%\System32\OneDriveSetup.exe /uninstall

• or 64 bit

%SystemRoot%\SysWOW64\OneDriveSetup.exe /uninstall